Study of interaction energies between residues of the active site of Hsp90 and geldanamycin analogues using quantum mechanics/molecular mechanics methods [version 1; peer review: 2 approved]

Background: Heat shock protein (Hsp90KDa) is a molecular chaperone involved in the process of cellular oncogenesis, hence its importance as a therapeutic target in clinical Hockey Accessories - Pucks trials.Geldanamycin is an inhibitor of Hsp90 chaperone activity, which binds to the ATP binding site in the N-terminal domain of Hsp90.However, geldan

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Detection of Pine Shoot Beetle (PSB) Stress on Pine Forests at Individual Tree Level using UAV-Based Hyperspectral Imagery and Lidar

In recent years, the outbreak of the pine shoot beetle (PSB), Tomicus spp., has caused serious shoots damage and the death of millions of trees in Yunnan pine forests in southwestern China.It is urgent to develop a convincing approach to accurately assess the shoot damage ratio (SDR) for monitoring the PSB insects at an early stage.Unmanned airborn

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Joint Learning of Correlation-Constrained Fuzzy Clustering and Discriminative Non-Negative Representation for Hyperspectral Band Selection

Hyperspectral band selection plays an important role in overcoming the curse of dimensionality.Recently, clustering-based band selection methods have shown promise in the selection of informative and representative bands from hyperspectral images (HSIs).However, most existing clustering-based band selection methods involve the clustering of origina

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